Electrical synapses are common between inhibitory neurons in the mammalian thalamus and neocortex. Synaptic modulation, which allows flexibility of communication between neurons, has been studied extensively at chemical synapses, but modulation of electrical synapses in the mammalian brain has barely been examined. We found that the activation of metabotropic glutamate receptors, via endogenous neurotransmitter or by agonist, causes long-term reduction of electrical synapse strength between the inhibitory neurons of the rat thalamic reticular nucleus.
Neuralink’s Bid to Trademark ‘Telepathy’ and ‘Telekinesis’ Faces Legal Issues
The brain implant company cofounded by Elon Musk filed to trademark the product names Telepathy and Telekinesis. But it turns out that another person had already filed to trademark those names.
The Human-in-the-Loop is Tired
On reward functions, dopamine, and what it actually feels like when the code starts writing itself
Alexander Shulgin
Dr. Alexander "Sasha" Theodore Shulgin or "Shura" was an American chemist, pharmacologist, psychopharmacologist, and author. Over the span of 50 years, he created more new psychedelic drugs than any other known person to date - nearly 250 by his own accounts.[1] Shulgin also rediscovered the drug MDMA and established its use as a tool in clinical psychedelic therapy for a short time.
Daily guide for projects - Neuromatch Academy: NeuroAI
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Mystified magicians of the mind
My conversation with neuroscientist Paul Cisek
I couldn’t sleep, then I tried cognitive shuffling | Psyche Notes to Self
The usual advice didn’t help my sleep problems, but then I tried an exercise that kickstarts the sleep-onset control system
An Undying Love For A Burning World, by Neurosis
Substituted tryptamines
Substituted tryptamines (or simply tryptamines) are a group of organic compounds that are based upon the tryptamine core structure. The class is composed of all the derivative compounds which can be formed by substituting one or more hydrogen atoms in the tryptamine core structure with other substituents. Natural tryptamines are found in most plants and animals, forming from the decarboxylation of the amino acid tryptophan.[1]
LettaBot - Your personal AI that remembers
Your personal AI with living memory. Remembers everything. Runs on your computer. Grows with you.
The Grug Brained Developer
this collection of thoughts on software development gathered by grug brain developer
How the hypercuriosity of ADHD may have helped humans thrive | Aeon Essays
ADHD isn’t merely a dysfunction. It’s best understood as an impulsive motivational drive for novel information
Mistral Vibe | AI coding agent for terminal, IDE by Mistral.
Agentic coding that understands your entire codebase. Build, test, and modernize autonomously.
AudioDharma - Love
Audio Dharma is an archive of Dharma talks given by Gil Fronsdal and various guest speakers at the Insight Meditation Center in Redwood City, CA. Each talk illuminates aspects of the Buddha's teachings. The purpose is the same that the Buddha had for his teachings, to guide us toward the end of suffering and the attainment of freedom.